Assay Detail
Binding
CHEMBL5331155
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Inhibition of mushroom tyrosinase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Azole inhibitors of mushroom and human tyrosinases: Current advances and prospects of drug development for melanogenic dermatological disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.74 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5395430 | — | — | 1 | 6.30 |
| CHEMBL5429559 | — | — | 1 | 6.22 |
| CHEMBL5423763 | — | — | 1 | 5.82 |
| CHEMBL5425119 | — | — | 1 | 5.80 |
| CHEMBL5430164 | — | — | 1 | 5.33 |
| CHEMBL5436607 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5395430 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5429559 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5423763 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5425119 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5430164 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5436607 | — | IC50 | = | 11180.0 | nM | 4.95 |