Assay Detail
Binding
CHEMBL5331165
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Binding affinity to human His-tagged tyrosinase CD expressed in HEK293 cells assessed as inhibition constant using L-DOPA as substrate by HTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azole inhibitors of mushroom and human tyrosinases: Current advances and prospects of drug development for melanogenic dermatological disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.17 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4743159 | — | — | 1 | 6.60 |
| CHEMBL450195 | RUCINOL | — | 1 | 5.05 |
| CHEMBL3961037 | — | — | 1 | 4.62 |
| CHEMBL443605 | HEXYLRESORCINOL | -1.0 | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4743159 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL450195 | RUCINOL | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL3961037 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL443605 | HEXYLRESORCINOL | Ki | = | 39000.0 | nM | 4.41 |