Assay Detail
Binding
CHEMBL5331242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NDM1 (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent advances in β-lactamase inhibitor chemotypes and inhibition modes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.99 | 10.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404362 | — | — | 1 | 10.48 |
| CHEMBL5408399 | — | — | 1 | 10.07 |
| CHEMBL5428850 | — | — | 1 | 8.90 |
| CHEMBL5415874 | — | — | 1 | 8.10 |
| CHEMBL5417591 | — | — | 1 | 6.89 |
| CHEMBL4087144 | — | — | 1 | 5.00 |
| CHEMBL434965 | D-CAPTOPRIL | — | 1 | 4.70 |
| CHEMBL4177035 | — | — | 1 | 4.61 |
| CHEMBL4169182 | — | — | 1 | 4.19 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404362 | — | IC50 | = | 0.033 | nM | 10.48 |
| CHEMBL5408399 | — | IC50 | = | 0.085 | nM | 10.07 |
| CHEMBL5428850 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL5415874 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL5417591 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4087144 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL434965 | D-CAPTOPRIL | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL4177035 | — | IC50 | = | 24810.0 | nM | 4.61 |
| CHEMBL4169182 | — | IC50 | = | 64800.0 | nM | 4.19 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 157400.0 | nM | - |