Assay Detail

CHEMBL5331307

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Binding

Inhibition of Enterobacter cloacae AmpC

ChEMBL ↗

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Target

Beta-lactamase (CHEMBL2725) ↗

Open DB target context

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Beta-lactamase (CHEMBL2725) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Beta-lactamase

CHEMBL2725

Anchored from Assay target.

Protein identity Beta-lactamase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Enterobacter cloacae
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Beta-lactamase (CHEMBL2725) ↗

Type	SINGLE PROTEIN
Organism	Enterobacter cloacae

Publication

Recent advances in β-lactamase inhibitor chemotypes and inhibition modes.

Li R, Chen X, Zhou C, Dai QQ, Yang L.
Eur J Med Chem (2022) 242 : 114677 -114677
PubMed 35988449 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.06	6.07

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3989959	NACUBACTAM	3.0	1	6.07
CHEMBL1689063	AVIBACTAM	4.0	1	6.04

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3989959	NACUBACTAM	IC50	=	845.0	nM	6.07
CHEMBL1689063	AVIBACTAM	IC50	=	923.0	nM	6.04