Assay Detail
Binding
CHEMBL5332365
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Inhibition of human beta-Catenin/GST-tagged TCF4 (unknown origin) protein-protein interaction incubated for 2 hrs by ELISA assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Recent advances of β-catenin small molecule inhibitors for cancer therapy: Current development and future perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.64 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2397074 | — | — | 1 | 6.19 |
| CHEMBL578512 | — | — | 1 | 6.10 |
| CHEMBL179197 | — | — | 1 | 5.62 |
| CHEMBL261214 | — | — | 1 | 5.50 |
| CHEMBL5397220 | — | — | 1 | 5.39 |
| CHEMBL2323033 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2397074 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL578512 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL179197 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL261214 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5397220 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2323033 | — | IC50 | = | 8700.0 | nM | 5.06 |