Assay Detail
Binding
CHEMBL5332380
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Inhibition of wild type beta-Catenin (142 to 686 residues) (unknown origin)/C-terminal fluorescein-labeled human TCF4 (7 to 51 residues) protein-protein interaction assessed as inhibition constant incubated for 30 mins by fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Recent advances of β-catenin small molecule inhibitors for cancer therapy: Current development and future perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.50 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3260853 | — | — | 1 | 5.87 |
| CHEMBL2323032 | — | — | 1 | 5.50 |
| CHEMBL3943439 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3260853 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL2323032 | — | Ki | = | 3140.0 | nM | 5.50 |
| CHEMBL3943439 | — | Ki | = | 7240.0 | nM | 5.14 |