Assay Detail
Functional
CHEMBL5332443
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 IIIB infected in human MT4 cells assessed as protection against virus-induced cytopathicity
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 41 | 6.54 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5440893 | — | — | 1 | 7.77 |
| CHEMBL5418664 | — | — | 1 | 7.64 |
| CHEMBL5413955 | — | — | 1 | 7.60 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.55 |
| CHEMBL5395649 | — | — | 1 | 7.55 |
| CHEMBL5433357 | — | — | 1 | 7.54 |
| CHEMBL5402037 | — | — | 1 | 7.44 |
| CHEMBL5407385 | — | — | 1 | 7.41 |
| CHEMBL5400179 | — | — | 1 | 7.37 |
| CHEMBL5419176 | — | — | 1 | 7.32 |
| CHEMBL5421562 | — | — | 1 | 7.28 |
| CHEMBL5426533 | — | — | 1 | 7.20 |
| CHEMBL5434617 | — | — | 1 | 7.15 |
| CHEMBL5403318 | — | — | 1 | 7.14 |
| CHEMBL5412702 | — | — | 1 | 7.07 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.07 |
| CHEMBL5429586 | — | — | 1 | 6.96 |
| CHEMBL5409916 | — | — | 1 | 6.85 |
| CHEMBL5402178 | — | — | 1 | 6.82 |
| CHEMBL5402928 | — | — | 1 | 6.82 |
| CHEMBL5435646 | — | — | 1 | 6.77 |
| CHEMBL5399229 | — | — | 1 | 6.77 |
| CHEMBL5397528 | — | — | 1 | 6.66 |
| CHEMBL5421746 | — | — | 1 | 6.47 |
| CHEMBL5398989 | — | — | 1 | 6.12 |
| CHEMBL5434913 | — | — | 1 | 6.11 |
| CHEMBL5434133 | — | — | 1 | 6.10 |
| CHEMBL5439881 | — | — | 1 | 6.08 |
| CHEMBL5408091 | — | — | 1 | 5.92 |
| CHEMBL5440098 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5440893 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5418664 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5413955 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5395649 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5433357 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5402037 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5407385 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5400179 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5419176 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5421562 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5426533 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5434617 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5403318 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5412702 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5429586 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5409916 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5402178 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5402928 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5435646 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5399229 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5397528 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5421746 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5398989 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5434913 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5434133 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5439881 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL5408091 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5440098 | — | EC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL5415230 | — | EC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL5426992 | — | EC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL5405381 | — | EC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL5394882 | — | EC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL5404887 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5397134 | — | EC50 | = | 6180.0 | nM | 5.21 |
| CHEMBL5401591 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL31871 | HEPT | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5427921 | — | EC50 | = | 22210.0 | nM | 4.65 |
| CHEMBL5399357 | — | EC50 | > | 44630.0 | nM | - |
| CHEMBL5425834 | — | EC50 | > | 30900.0 | nM | - |