Assay Detail
Functional
CHEMBL5332567
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Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of N3-substituted quinazolinone derivatives as potential Bloom's Syndrome protein (BLM) helicase inhibitor for sensitization treatment of colorectal cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.43 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423610 | — | — | 1 | 5.55 |
| CHEMBL5424781 | — | — | 1 | 5.54 |
| CHEMBL5433468 | — | — | 1 | 5.52 |
| CHEMBL5440285 | — | — | 1 | 5.28 |
| CHEMBL4633662 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423610 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5424781 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5433468 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5440285 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4633662 | — | IC50 | = | 5600.0 | nM | 5.25 |