Assay Detail
Toxicity
CHEMBL5332643
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Cytotoxicity against mouse NIH3T3 cells assessed as inhibition of cell growth measured for 24 hrs by neutral red uptake assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.51 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5430250 | — | — | 1 | 5.19 |
| CHEMBL2165094 | — | — | 1 | 4.72 |
| CHEMBL5420923 | — | — | 1 | 4.46 |
| CHEMBL5401122 | — | — | 1 | 4.41 |
| CHEMBL5436635 | — | — | 1 | 4.35 |
| CHEMBL5417524 | — | — | 1 | 4.34 |
| CHEMBL2165084 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5430250 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2165094 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL5420923 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL5401122 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL5436635 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL5417524 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL2165084 | — | IC50 | = | 75000.0 | nM | 4.12 |