Assay Detail
Binding
CHEMBL5332745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATM (unknown origin) using peptide as substrate preincubated for 10 mins followed by substrate addition by microplate reader analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.15 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5425498 | — | — | 1 | 6.29 |
| CHEMBL5423608 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5425498 | — | IC50 | = | 516.0 | nM | 6.29 |
| CHEMBL5423608 | — | IC50 | = | 1000.0 | nM | 6.00 |