Assay Detail
Binding
CHEMBL5332829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NPP2 expressed in COS-7 cells using pNP-TMP as substrate preincubated for 10 mins followed by substrate addition and measured after 35 mins by microplate reader analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of new adamantyl derivatives as promising antiproliferative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.35 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117754 | — | — | 1 | 7.22 |
| CHEMBL5432925 | — | — | 1 | 5.97 |
| CHEMBL5404116 | — | — | 1 | 5.87 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117754 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5432925 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5404116 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | - | — | - |