Assay Detail
Binding
CHEMBL5333104
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Inhibition of human Cathepsin L using Cbz-Phe-Arg-AMC as substrate assessed as inhibition constant measured for 10 mins by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.93 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436027 | — | — | 1 | 6.60 |
| CHEMBL5401213 | — | — | 1 | 5.72 |
| CHEMBL5423619 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436027 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL5401213 | — | Ki | = | 1920.0 | nM | 5.72 |
| CHEMBL5423619 | — | Ki | = | 3380.0 | nM | 5.47 |