Assay Detail
Functional
CHEMBL5333915
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Antimycobacterial activity against Mycobacterium tuberculosis HN878 assessed as inhibition of mycobacterial growth incubated for 5 days in presence of 50 uM undecaprenyl phosphate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.21 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261880 | — | — | 1 | 6.27 |
| CHEMBL3261881 | — | — | 1 | 5.55 |
| CHEMBL561057 | SQ109 | 2.0 | 1 | 5.21 |
| CHEMBL5395162 | — | — | 1 | 5.10 |
| CHEMBL5403488 | — | — | 1 | 5.06 |
| CHEMBL5414003 | — | — | 1 | 5.06 |
| CHEMBL1087059 | — | — | 1 | 4.80 |
| CHEMBL5432995 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261880 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3261881 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL561057 | SQ109 | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5395162 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5403488 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5414003 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1087059 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5432995 | — | IC50 | = | 24000.0 | nM | 4.62 |