Assay Detail
Binding
CHEMBL5334341
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum DHODH
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL3588732) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum (isolate 3D7) |
Publication
Basic Nitrogen (BaN) Is a Key Property of Antimalarial Chemical Space.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.06 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636879 | — | — | 1 | 7.75 |
| CHEMBL4633246 | — | — | 1 | 7.70 |
| CHEMBL4643370 | — | — | 1 | 7.30 |
| CHEMBL4642145 | — | — | 1 | 7.00 |
| CHEMBL600689 | — | — | 1 | 6.57 |
| CHEMBL4636244 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636879 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4633246 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4643370 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4642145 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL600689 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4636244 | — | IC50 | = | 880.0 | nM | 6.06 |