Assay Detail
Binding
CHEMBL5334565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Irreversible inhibition of human STS expressed in human T47D cells using [3H]E1S as substrate preincubated for 2 hr followed by substrate addition measured after 24 hrs in presence of E1S by HPLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for <i>In Vivo</i> Proof-of-Principle Studies in an Endometriosis Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.91 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071245 | — | — | 1 | 7.80 |
| CHEMBL5394384 | — | — | 1 | 7.10 |
| CHEMBL5429832 | — | — | 1 | 6.38 |
| CHEMBL5440157 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071245 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5394384 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5429832 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5440157 | — | IC50 | = | 460.0 | nM | 6.34 |