Assay Detail
Functional
CHEMBL5334781
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition in human LNCaP cells incubated for 4 days by WST-8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.70 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404267 | — | — | 1 | 7.89 |
| CHEMBL4862963 | BAVDEGALUTAMIDE | 1.0 | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404267 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4862963 | BAVDEGALUTAMIDE | IC50 | = | 32.0 | nM | 7.50 |