Assay Detail
Functional
CHEMBL5335290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human COLO 205 cells incubated for 48 hrs by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Glucose Transporter Inhibitor-SN38 Conjugates for Targeting Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.12 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | 2.0 | 1 | 9.12 |
| CHEMBL5415097 | — | — | 1 | 6.24 |
| CHEMBL5412412 | — | — | 1 | 6.19 |
| CHEMBL5430991 | — | — | 1 | 5.34 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 5.00 |
| CHEMBL5440783 | — | — | 1 | 4.81 |
| CHEMBL245067 | PHLORIZIN | — | 1 | - |
| CHEMBL5440668 | — | — | 1 | - |
| CHEMBL5094407 | — | — | 1 | - |
| CHEMBL5077765 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL837 | 7-ETHYL-10-HYDROXYCAMPTOTHECIN | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL5415097 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5412412 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5430991 | — | IC50 | = | 4590.0 | nM | 5.34 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5440783 | — | IC50 | = | 15430.0 | nM | 4.81 |
| CHEMBL245067 | PHLORIZIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL5440668 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5094407 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5077765 | — | IC50 | > | 100000.0 | nM | - |