Assay Detail
Binding
CHEMBL5335367
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Displacement of [3H]SCH-23390 from human dopamine D1 receptor assessed as inhibition constant
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Selective Dopamine Receptor Ligands Derived from (-)-Stepholidine via C-3 Alkoxylation and C-3/C-9 Dialkoxylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.20 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8514 | BUTACLAMOL | 2.0 | 1 | 8.64 |
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 8.23 |
| CHEMBL5435602 | — | — | 1 | 8.19 |
| CHEMBL5439212 | — | — | 1 | 7.96 |
| CHEMBL5410387 | — | — | 1 | 7.82 |
| CHEMBL5433001 | — | — | 1 | 7.77 |
| CHEMBL5436253 | — | — | 1 | 7.72 |
| CHEMBL5402269 | — | — | 1 | 7.70 |
| CHEMBL5399568 | — | — | 1 | 7.51 |
| CHEMBL5416700 | — | — | 1 | 7.51 |
| CHEMBL5428803 | — | — | 1 | 7.47 |
| CHEMBL5410716 | — | — | 1 | 7.38 |
| CHEMBL5395272 | — | — | 1 | 7.36 |
| CHEMBL5399166 | — | — | 1 | 7.28 |
| CHEMBL5438487 | — | — | 1 | 7.24 |
| CHEMBL5425375 | — | — | 1 | 7.17 |
| CHEMBL5423880 | — | — | 1 | 7.10 |
| CHEMBL5394838 | — | — | 1 | 7.07 |
| CHEMBL5399422 | — | — | 1 | 7.06 |
| CHEMBL5420387 | — | — | 1 | 7.04 |
| CHEMBL5412881 | — | — | 1 | 6.97 |
| CHEMBL5398357 | — | — | 1 | 6.96 |
| CHEMBL5399393 | — | — | 1 | 6.83 |
| CHEMBL5396616 | — | — | 1 | 6.81 |
| CHEMBL5423775 | — | — | 1 | 6.35 |
| CHEMBL5437148 | — | — | 1 | 6.33 |
| CHEMBL5439661 | — | — | 1 | 6.18 |
| CHEMBL5409939 | — | — | 1 | 6.17 |
| CHEMBL5420515 | — | — | 1 | 6.09 |
| CHEMBL5399933 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8514 | BUTACLAMOL | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL5435602 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL5439212 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5410387 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL5433001 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL5436253 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL5402269 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL5399568 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL5416700 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL5428803 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL5410716 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL5395272 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL5399166 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL5438487 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL5425375 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL5423880 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL5394838 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL5399422 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL5420387 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL5412881 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL5398357 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL5399393 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL5396616 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL5423775 | — | Ki | = | 447.0 | nM | 6.35 |
| CHEMBL5437148 | — | Ki | = | 465.0 | nM | 6.33 |
| CHEMBL5439661 | — | Ki | = | 664.0 | nM | 6.18 |
| CHEMBL5409939 | — | Ki | = | 683.0 | nM | 6.17 |
| CHEMBL5420515 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL5399933 | — | Ki | = | 1014.0 | nM | 5.99 |