Assay Detail
Binding
CHEMBL5335576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]UR-KK200 from human Y4 receptor expressed in CHO-Gqi5-mtAQE cells measured after 90 mins by MicroBeta plate counter based competition binding assay
13
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Stereochemistry-Driven Interactions of α,γ-Peptide Ligands with the Neuropeptide Y Y<sub>4</sub>-Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.11 | 10.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4856311 | — | — | 1 | 10.48 |
| CHEMBL4873376 | — | — | 1 | 10.32 |
| CHEMBL5426658 | — | — | 2 | 9.19 |
| CHEMBL4633593 | — | — | 2 | 8.47 |
| CHEMBL4639709 | — | — | 1 | 8.47 |
| CHEMBL5418083 | — | — | 2 | 7.93 |
| CHEMBL5431678 | — | — | 2 | 6.48 |
| CHEMBL5434829 | — | — | 2 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4856311 | — | Ki | = | 0.033 | nM | 10.48 |
| CHEMBL4873376 | — | Ki | = | 0.048 | nM | 10.32 |
| CHEMBL5426658 | — | Ki | = | 0.6457 | nM | 9.19 |
| CHEMBL5426658 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL4633593 | — | Ki | = | 3.388 | nM | 8.47 |
| CHEMBL4633593 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL4639709 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL5418083 | — | Ki | = | 11.75 | nM | 7.93 |
| CHEMBL5418083 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL5431678 | — | Ki | = | 331.13 | nM | 6.48 |
| CHEMBL5431678 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL5434829 | — | Ki | = | 891.25 | nM | 6.05 |
| CHEMBL5434829 | — | Ki | = | 910.0 | nM | 6.04 |