Assay Detail
Binding
CHEMBL5335577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist potency at human Y4 receptor expressed in HEK293T-NlucN-mGSi/Y4R-NlucC cells by miniGsi protein recruitment assay
11
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Stereochemistry-Driven Interactions of α,γ-Peptide Ligands with the Neuropeptide Y Y<sub>4</sub>-Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.38 | 9.00 |
| pEC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4856311 | — | — | 1 | 9.00 |
| CHEMBL4873376 | — | — | 1 | 8.77 |
| CHEMBL5426658 | — | — | 2 | 7.73 |
| CHEMBL4633593 | — | — | 2 | 6.98 |
| CHEMBL4639709 | — | — | 1 | 6.77 |
| CHEMBL5418083 | — | — | 2 | 6.33 |
| CHEMBL5431678 | — | — | 1 | - |
| CHEMBL5434829 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4856311 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4873376 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5426658 | — | EC50 | = | 18.62 | nM | 7.73 |
| CHEMBL5426658 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4633593 | — | EC50 | = | 104.71 | nM | 6.98 |
| CHEMBL4633593 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4639709 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5418083 | — | EC50 | = | 467.74 | nM | 6.33 |
| CHEMBL5418083 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5431678 | — | pEC50 | - | — | - | |
| CHEMBL5434829 | — | pEC50 | - | — | - |