Assay Detail
Functional
CHEMBL5335597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human LNCaP cells incubated for 6 days by CellTiter-Glo assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.02 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5413706 | — | — | 1 | 6.49 |
| CHEMBL5407635 | — | — | 1 | 6.47 |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | 6.46 |
| CHEMBL5404028 | — | — | 1 | 6.45 |
| CHEMBL5412123 | — | — | 1 | 6.38 |
| CHEMBL5418451 | — | — | 1 | 6.37 |
| CHEMBL5440764 | — | — | 1 | 6.36 |
| CHEMBL5400148 | — | — | 1 | 6.33 |
| CHEMBL5400213 | — | — | 1 | 6.33 |
| CHEMBL5414716 | — | — | 1 | 6.32 |
| CHEMBL5411468 | — | — | 1 | 6.28 |
| CHEMBL5418000 | — | — | 1 | 6.22 |
| CHEMBL5409426 | — | — | 1 | 6.22 |
| CHEMBL5420162 | — | — | 1 | 6.19 |
| CHEMBL5402908 | — | — | 1 | 6.13 |
| CHEMBL5425503 | — | — | 1 | 6.12 |
| CHEMBL5422953 | — | — | 1 | 6.09 |
| CHEMBL5408835 | — | — | 1 | 6.02 |
| CHEMBL5405337 | — | — | 1 | 5.95 |
| CHEMBL5439614 | — | — | 1 | 5.91 |
| CHEMBL5418261 | — | — | 1 | 5.86 |
| CHEMBL5417658 | — | — | 1 | 5.83 |
| CHEMBL5425370 | — | — | 1 | 5.74 |
| CHEMBL5427286 | — | — | 1 | 5.71 |
| CHEMBL5420844 | — | — | 1 | 5.68 |
| CHEMBL5433307 | — | — | 1 | 5.63 |
| CHEMBL5395949 | — | — | 1 | 5.62 |
| CHEMBL5422480 | — | — | 1 | 5.46 |
| CHEMBL5428471 | — | — | 1 | 5.44 |
| CHEMBL5417407 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5413706 | — | IC50 | = | 327.2 | nM | 6.49 |
| CHEMBL5407635 | — | IC50 | = | 341.1 | nM | 6.47 |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | = | 349.8 | nM | 6.46 |
| CHEMBL5404028 | — | IC50 | = | 355.7 | nM | 6.45 |
| CHEMBL5412123 | — | IC50 | = | 417.8 | nM | 6.38 |
| CHEMBL5418451 | — | IC50 | = | 427.1 | nM | 6.37 |
| CHEMBL5440764 | — | IC50 | = | 435.8 | nM | 6.36 |
| CHEMBL5400148 | — | IC50 | = | 470.9 | nM | 6.33 |
| CHEMBL5400213 | — | IC50 | = | 472.8 | nM | 6.33 |
| CHEMBL5414716 | — | IC50 | = | 475.0 | nM | 6.32 |
| CHEMBL5411468 | — | IC50 | = | 526.7 | nM | 6.28 |
| CHEMBL5418000 | — | IC50 | = | 607.9 | nM | 6.22 |
| CHEMBL5409426 | — | IC50 | = | 595.1 | nM | 6.22 |
| CHEMBL5420162 | — | IC50 | = | 642.8 | nM | 6.19 |
| CHEMBL5402908 | — | IC50 | = | 734.5 | nM | 6.13 |
| CHEMBL5425503 | — | IC50 | = | 752.5 | nM | 6.12 |
| CHEMBL5422953 | — | IC50 | = | 818.7 | nM | 6.09 |
| CHEMBL5408835 | — | IC50 | = | 958.0 | nM | 6.02 |
| CHEMBL5405337 | — | IC50 | = | 1115.0 | nM | 5.95 |
| CHEMBL5439614 | — | IC50 | = | 1245.0 | nM | 5.91 |
| CHEMBL5418261 | — | IC50 | = | 1375.0 | nM | 5.86 |
| CHEMBL5417658 | — | IC50 | = | 1486.0 | nM | 5.83 |
| CHEMBL5425370 | — | IC50 | = | 1831.0 | nM | 5.74 |
| CHEMBL5427286 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL5420844 | — | IC50 | = | 2095.0 | nM | 5.68 |
| CHEMBL5433307 | — | IC50 | = | 2346.0 | nM | 5.63 |
| CHEMBL5395949 | — | IC50 | = | 2424.0 | nM | 5.62 |
| CHEMBL5422480 | — | IC50 | = | 3441.0 | nM | 5.46 |
| CHEMBL5428471 | — | IC50 | = | 3651.0 | nM | 5.44 |
| CHEMBL5417407 | — | IC50 | = | 4632.0 | nM | 5.33 |
| CHEMBL5426540 | — | IC50 | = | 6554.0 | nM | 5.18 |
| CHEMBL5431113 | — | IC50 | > | 10000.0 | nM | - |