Assay Detail
Binding
CHEMBL5336136
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Inhibition of human Cathepsin L using HiLyte Fluor488TM as substrate pre-incubated for 60 mins in presence of GSH followed by substrate addition measured after 30 mins by fluorescence based assay
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.73 | 9.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2365410 | — | — | 2 | 9.16 |
| CHEMBL5436771 | — | — | 2 | 4.37 |
| CHEMBL4590273 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2365410 | — | IC50 | = | 0.6918 | nM | 9.16 |
| CHEMBL2365410 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5436771 | — | IC50 | = | 42800.0 | nM | 4.37 |
| CHEMBL5436771 | — | IC50 | = | 42657.95 | nM | 4.37 |
| CHEMBL4590273 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL4590273 | — | IC50 | = | 123026.88 | nM | - |