Assay Detail
Functional
CHEMBL5336144
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Antiviral activity against hCoV-229E infected in human Huh-7 cells assessed as inhibition of viral growth incubated for 6 hrs by renilla luciferase assay based berthold luminometer
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus 229E |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.64 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2365410 | — | — | 1 | 7.40 |
| CHEMBL4590273 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2365410 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4590273 | — | IC50 | = | 1340.0 | nM | 5.87 |