Assay Detail
Functional
CHEMBL5336305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 3B infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.43 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314972 | DEUREMIDEVIR HYDROBROMIDE | 1.0 | 1 | 6.62 |
| CHEMBL5314500 | MINDEUDESIVIR | 2.0 | 1 | 6.46 |
| CHEMBL5400945 | — | — | 1 | 6.41 |
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314972 | DEUREMIDEVIR HYDROBROMIDE | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5314500 | MINDEUDESIVIR | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5400945 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2016757 | GS-441524 | EC50 | = | 590.0 | nM | 6.23 |