Assay Detail
Binding
CHEMBL5336352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-tagged SARS-CoV-2 3CLpro by microplate reader assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.35 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456 | ETHACRYNIC ACID | 4.0 | 1 | 5.96 |
| CHEMBL154 | NAPROXEN | 4.0 | 1 | 5.46 |
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | 5.42 |
| CHEMBL1200397 | BUTENAFINE HYDROCHLORIDE | 4.0 | 1 | 5.27 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | 5.25 |
| CHEMBL542118 | — | — | 1 | 5.06 |
| CHEMBL282042 | SAQUINAVIR MESYLATE | 4.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456 | ETHACRYNIC ACID | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL154 | NAPROXEN | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL1467 | ALLOPURINOL | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL1200397 | BUTENAFINE HYDROCHLORIDE | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | IC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL542118 | — | IC50 | = | 8640.0 | nM | 5.06 |
| CHEMBL282042 | SAQUINAVIR MESYLATE | IC50 | = | 9920.0 | nM | 5.00 |