Assay Detail
Binding
CHEMBL5336370
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length GST-tagged SARS-CoV-2 Main protease expressed in Escherichia coli
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.17 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5412571 | — | — | 1 | 8.52 |
| CHEMBL5076204 | — | — | 1 | 7.52 |
| CHEMBL4764751 | — | — | 1 | 7.40 |
| CHEMBL4796938 | — | — | 1 | 7.30 |
| CHEMBL5192273 | — | — | 1 | 6.85 |
| CHEMBL5180964 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5412571 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5076204 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4764751 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4796938 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5192273 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5180964 | — | IC50 | = | 3880.0 | nM | 5.41 |