Assay Detail
Binding
CHEMBL5336848
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Inhibition of mouse GAT2
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.87 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5431496 | — | — | 1 | 5.22 |
| CHEMBL5430628 | — | — | 1 | 4.89 |
| CHEMBL3403559 | — | — | 2 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5431496 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5430628 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3403559 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3403559 | — | IC50 | = | 21379.62 | nM | 4.67 |