Assay Detail
Toxicity
CHEMBL5336981
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Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 27 hrs by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT<sub>6</sub> Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.28 | 4.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405562 | — | — | 1 | 4.39 |
| CHEMBL5436003 | — | — | 1 | 4.27 |
| CHEMBL5419441 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405562 | — | IC50 | = | 40600.0 | nM | 4.39 |
| CHEMBL5436003 | — | IC50 | = | 53200.0 | nM | 4.27 |
| CHEMBL5419441 | — | IC50 | = | 66100.0 | nM | 4.18 |