Assay Detail
Binding
CHEMBL5337349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MLK3 by ATP-competitive binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 11 (CHEMBL2708) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis of new 3H-imidazo[4,5-b]pyridine derivatives and evaluation of their inhibitory properties as mixed lineage kinase 3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.51 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5403058 | — | — | 1 | 8.22 |
| CHEMBL5397520 | — | — | 1 | 8.22 |
| CHEMBL5417152 | — | — | 1 | 8.10 |
| CHEMBL5436267 | — | — | 1 | 7.96 |
| CHEMBL5409050 | — | — | 1 | 7.85 |
| CHEMBL5416972 | — | — | 1 | 7.85 |
| CHEMBL5435826 | — | — | 1 | 7.77 |
| CHEMBL5397819 | — | — | 1 | 7.70 |
| CHEMBL5421283 | — | — | 1 | 7.60 |
| CHEMBL5436833 | — | — | 1 | 7.58 |
| CHEMBL5440213 | — | — | 1 | 7.57 |
| CHEMBL5410283 | — | — | 1 | 7.24 |
| CHEMBL5407648 | — | — | 1 | 7.20 |
| CHEMBL5408099 | — | — | 1 | 7.08 |
| CHEMBL235641 | — | — | 1 | 6.84 |
| CHEMBL5401171 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5403058 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5397520 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5417152 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5436267 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5409050 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5416972 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5435826 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5397819 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5421283 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5436833 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5440213 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5410283 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5407648 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5408099 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL235641 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL5401171 | — | IC50 | = | 4655.0 | nM | 5.33 |