Assay Detail
Binding
CHEMBL5337350
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MLK1 (unknown origin)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 9 (CHEMBL2872) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis of new 3H-imidazo[4,5-b]pyridine derivatives and evaluation of their inhibitory properties as mixed lineage kinase 3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.39 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436267 | — | — | 1 | 7.85 |
| CHEMBL5397819 | — | — | 1 | 7.85 |
| CHEMBL5436833 | — | — | 1 | 7.82 |
| CHEMBL5417152 | — | — | 1 | 7.80 |
| CHEMBL5416972 | — | — | 1 | 7.66 |
| CHEMBL5435826 | — | — | 1 | 7.66 |
| CHEMBL5440213 | — | — | 1 | 7.62 |
| CHEMBL5421283 | — | — | 1 | 7.60 |
| CHEMBL5403058 | — | — | 1 | 7.47 |
| CHEMBL5409050 | — | — | 1 | 7.47 |
| CHEMBL5397520 | — | — | 1 | 7.33 |
| CHEMBL5407648 | — | — | 1 | 7.19 |
| CHEMBL5408099 | — | — | 1 | 6.87 |
| CHEMBL5401171 | — | — | 1 | 5.23 |
| CHEMBL5410283 | — | — | 1 | - |
| CHEMBL3613594 | — | — | 1 | - |
| CHEMBL235641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436267 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5397819 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5436833 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5417152 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5416972 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5435826 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5440213 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5421283 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5403058 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5409050 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5397520 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5407648 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5408099 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL5401171 | — | IC50 | = | 5922.0 | nM | 5.23 |
| CHEMBL5410283 | — | IC50 | - | — | - | |
| CHEMBL3613594 | — | IC50 | - | — | - | |
| CHEMBL235641 | — | IC50 | - | — | - |