Review anchor
Mitogen-activated protein kinase kinase kinase 9
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
Evidence Snapshot
Mitogen-activated protein kinase kinase kinase 9
CHEMBL2872
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase 9 as ChEMBL target CHEMBL2872, mapped to UniProt P80192. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL2872
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P80192
Mitogen-activated protein kinase kinase kinase 9
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Mitogen-activated protein kinase kinase kinase 9 matters
Mitogen-activated protein kinase kinase kinase 9 is reviewed as Mitogen-activated protein kinase kinase kinase 9 (UniProt P80192); Mitogen-activated protein kinase kinase kinase 9 shows clinical signal disease relevance led by Parkinson disease.; 1 linked drug keep this evidence frame grounded.; the current evidence base includes 9 approved drugs, 786 compounds, and 346 assays, with lead potency reaching pChEMBL 9.3.
Protein context
Mitogen-activated protein kinase kinase kinase 9
Mitogen-activated protein kinase kinase kinase 9 Sequence length is 1104 aa.
Review this target as Mitogen-activated protein kinase kinase kinase 9, mapped to UniProt P80192. Sequence length is 1104 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P80192
Protein
Disease context
Parkinson disease
Mitogen-activated protein kinase kinase kinase 9 shows clinical signal disease relevance led by Parkinson disease. 1 linked drug keep the rationale reviewable. Linked drugs include CEP-1347.
Start review with Parkinson disease because it currently carries clinical signal support. Linked drugs include CEP-1347. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target record
Clinical signal
1 linked drug
Activity base
Portfolio and assay base
ChEMBL currently tracks 9 approved drugs, 786 compounds, and 346 assays for this target. The dominant activity type is IC50. CHEMBL388978 is the current potency anchor at pChEMBL 9.3.
Use CHEMBL388978 as the tractability anchor when discussing potency (pChEMBL 9.3).
Activity source · ChEMBL 36 via Core Engine
9 approved
pChEMBL 9.3
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Mitogen-activated protein kinase kinase kinase 9 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P80192, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need to see why Parkinson disease is currently treated as clinical signal support.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
786
Total Compounds
346
Total Assays
9
Approved Drugs
IC50: 147.0, KI: 2.0, KD: 122.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL388978
|
9.3 | IC50 | — |
|
|
No preferred name
CHEMBL4465866
|
8.7 | Kd | — |
|
|
No preferred name
CHEMBL4576489
|
8.5 | Kd | — |
|
|
No preferred name
CHEMBL603469
|
8.5 | Kd | Clinical |
|
|
No preferred name
CHEMBL4116008
|
8.4 | IC50 | Clinical |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
MIDOSTAURIN
CHEMBL608533
|
2017 |
|
|
BRIGATINIB
CHEMBL3545311
|
2017 |
|
|
NINTEDANIB
CHEMBL502835
|
2014 |
|
|
PAZOPANIB
CHEMBL477772
|
2009 |
Source Header