Assay Detail
Binding
CHEMBL5337843
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Ig-tagged PD-1 (unknown origin)/His-tagged PD-L1 (unknown origin) protein-protein interaction preincubated with PD-L1 for 15 mins followed by PD-1 addition measured after 15 mins by HTRF assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Development and <i>In Vivo</i> Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.41 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081869 | — | — | 1 | 8.22 |
| CHEMBL5435961 | — | — | 1 | 8.22 |
| CHEMBL5429887 | — | — | 1 | 8.22 |
| CHEMBL4089730 | — | — | 1 | 7.75 |
| CHEMBL5409531 | — | — | 1 | 6.96 |
| CHEMBL5437019 | — | — | 1 | 6.96 |
| CHEMBL5414215 | — | — | 1 | 6.96 |
| CHEMBL5401188 | — | — | 1 | 6.96 |
| CHEMBL5431528 | — | — | 1 | 6.96 |
| CHEMBL4099869 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081869 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5435961 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5429887 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4089730 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5409531 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5437019 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5414215 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5401188 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5431528 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4099869 | — | IC50 | = | 146.0 | nM | 6.84 |