Assay Detail
Binding
CHEMBL5337854
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PD-1 binding to human PD-L1 by HTRF assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Development and <i>In Vivo</i> Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.53 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419797 | — | — | 1 | 8.43 |
| CHEMBL5412235 | — | — | 1 | 8.39 |
| CHEMBL5432909 | — | — | 1 | 8.31 |
| CHEMBL5436822 | — | — | 1 | 8.22 |
| CHEMBL5436514 | — | — | 1 | 8.21 |
| CHEMBL5425865 | — | — | 1 | 8.21 |
| CHEMBL4638650 | — | — | 1 | 8.17 |
| CHEMBL5424869 | — | — | 1 | 8.11 |
| CHEMBL5414835 | — | — | 1 | 8.09 |
| CHEMBL5430973 | — | — | 1 | 8.04 |
| CHEMBL5416482 | — | — | 1 | 7.99 |
| CHEMBL4865206 | — | — | 1 | 7.96 |
| CHEMBL5412039 | — | — | 1 | 7.92 |
| CHEMBL5424916 | — | — | 1 | 7.92 |
| CHEMBL5400124 | — | — | 1 | 7.80 |
| CHEMBL5426426 | — | — | 1 | 7.80 |
| CHEMBL5439310 | — | — | 1 | 7.72 |
| CHEMBL5410844 | — | — | 1 | 7.54 |
| CHEMBL5396887 | — | — | 1 | 7.52 |
| CHEMBL5398595 | — | — | 1 | 7.34 |
| CHEMBL5408386 | — | — | 1 | 7.30 |
| CHEMBL5408730 | — | — | 1 | 7.30 |
| CHEMBL4089730 | — | — | 1 | 7.00 |
| CHEMBL3582252 | — | — | 1 | 6.70 |
| CHEMBL5429159 | — | — | 1 | 6.68 |
| CHEMBL5398056 | — | — | 1 | 6.23 |
| CHEMBL5418648 | — | — | 1 | 5.89 |
| CHEMBL5422336 | — | — | 1 | 5.89 |
| CHEMBL5440112 | — | — | 1 | 5.77 |
| CHEMBL4092122 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419797 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5412235 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5432909 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL5436822 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5436514 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5425865 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4638650 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5424869 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL5414835 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL5430973 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5416482 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL4865206 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5412039 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5424916 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5426426 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5400124 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5439310 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5410844 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5396887 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5398595 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5408386 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5408730 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4089730 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3582252 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL5429159 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL5398056 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL5418648 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5422336 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL5440112 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5424402 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5423262 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5436818 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5436927 | — | IC50 | - | — | - | |
| CHEMBL5427994 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5414313 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5395503 | — | IC50 | - | — | - | |
| CHEMBL5394828 | — | IC50 | - | — | - | |
| CHEMBL4441950 | — | IC50 | - | — | - | |
| CHEMBL5434250 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4092122 | — | IC50 | - | — | - |