Assay Detail
Binding
CHEMBL5338149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured every min for 10 mins by Ellman's method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Erythrocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.48 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.41 |
| CHEMBL5414144 | — | — | 1 | 4.96 |
| CHEMBL5407180 | — | — | 1 | 4.85 |
| CHEMBL5407164 | — | — | 1 | 4.70 |
| CHEMBL5434888 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5414144 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5407180 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5407164 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5434888 | — | IC50 | = | 34000.0 | nM | 4.47 |