Assay Detail
Binding
CHEMBL5338273
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Inhibition of SIK2 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase SIK2 (CHEMBL5699) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.06 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5407103 | — | — | 1 | 9.40 |
| CHEMBL5405960 | — | — | 1 | 8.72 |
| CHEMBL5398906 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5407103 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5405960 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5398906 | — | IC50 | < | 1.0 | nM | - |