Assay Detail
Binding
CHEMBL5338518
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 60 min by HTRF assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Evaluation of 8-(<i>o</i>-Tolyl)quinazoline Derivatives as Small-Molecule PD-1/PD-L1 Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.28 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5411364 | — | — | 1 | 7.92 |
| CHEMBL4071326 | — | — | 1 | 7.91 |
| CHEMBL5401055 | — | — | 1 | 7.62 |
| CHEMBL5439650 | — | — | 1 | 7.60 |
| CHEMBL5434956 | — | — | 1 | 7.52 |
| CHEMBL5437145 | — | — | 1 | 7.47 |
| CHEMBL5424368 | — | — | 1 | 7.42 |
| CHEMBL5190791 | — | — | 1 | 7.39 |
| CHEMBL5414129 | — | — | 1 | 7.35 |
| CHEMBL5424496 | — | — | 1 | 7.34 |
| CHEMBL5420556 | — | — | 1 | 7.33 |
| CHEMBL5431236 | — | — | 1 | 7.31 |
| CHEMBL5436487 | — | — | 1 | 7.29 |
| CHEMBL5423631 | — | — | 1 | 7.26 |
| CHEMBL5402715 | — | — | 1 | 7.22 |
| CHEMBL5395052 | — | — | 1 | 7.21 |
| CHEMBL5406531 | — | — | 1 | 7.12 |
| CHEMBL4089730 | — | — | 1 | 7.06 |
| CHEMBL5405915 | — | — | 1 | 7.00 |
| CHEMBL5434403 | — | — | 1 | 6.98 |
| CHEMBL5426450 | — | — | 1 | 6.95 |
| CHEMBL5418851 | — | — | 1 | 6.78 |
| CHEMBL5412273 | — | — | 1 | 6.41 |
| CHEMBL5396580 | — | — | 1 | - |
| CHEMBL5411201 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5411364 | — | IC50 | = | 12.13 | nM | 7.92 |
| CHEMBL4071326 | — | IC50 | = | 12.32 | nM | 7.91 |
| CHEMBL5401055 | — | IC50 | = | 23.78 | nM | 7.62 |
| CHEMBL5439650 | — | IC50 | = | 25.31 | nM | 7.60 |
| CHEMBL5434956 | — | IC50 | = | 30.17 | nM | 7.52 |
| CHEMBL5437145 | — | IC50 | = | 33.86 | nM | 7.47 |
| CHEMBL5424368 | — | IC50 | = | 37.68 | nM | 7.42 |
| CHEMBL5190791 | — | IC50 | = | 40.82 | nM | 7.39 |
| CHEMBL5414129 | — | IC50 | = | 44.78 | nM | 7.35 |
| CHEMBL5424496 | — | IC50 | = | 46.17 | nM | 7.34 |
| CHEMBL5420556 | — | IC50 | = | 47.18 | nM | 7.33 |
| CHEMBL5431236 | — | IC50 | = | 48.5 | nM | 7.31 |
| CHEMBL5436487 | — | IC50 | = | 51.49 | nM | 7.29 |
| CHEMBL5423631 | — | IC50 | = | 55.49 | nM | 7.26 |
| CHEMBL5402715 | — | IC50 | = | 59.68 | nM | 7.22 |
| CHEMBL5395052 | — | IC50 | = | 61.37 | nM | 7.21 |
| CHEMBL5406531 | — | IC50 | = | 75.82 | nM | 7.12 |
| CHEMBL4089730 | — | IC50 | = | 87.2 | nM | 7.06 |
| CHEMBL5405915 | — | IC50 | = | 100.55 | nM | 7.00 |
| CHEMBL5434403 | — | IC50 | = | 105.18 | nM | 6.98 |
| CHEMBL5426450 | — | IC50 | = | 111.99 | nM | 6.95 |
| CHEMBL5418851 | — | IC50 | = | 166.7 | nM | 6.78 |
| CHEMBL5412273 | — | IC50 | = | 390.05 | nM | 6.41 |
| CHEMBL5396580 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5411201 | — | IC50 | > | 1000.0 | nM | - |