Assay Detail
Binding
CHEMBL5338633
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Inhibition of full-length IRAK4 (unknown origin) in presence of ATP by DELFIA assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Interleukin-1 receptor-associated kinase 4 (CHEMBL3778) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.43 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4066705 | — | — | 1 | 10.00 |
| CHEMBL4081711 | ZIMLOVISERTIB | 2.0 | 1 | 9.70 |
| CHEMBL4093120 | — | — | 1 | 9.52 |
| CHEMBL4091434 | — | — | 1 | 9.30 |
| CHEMBL4085199 | — | — | 1 | 9.22 |
| CHEMBL4071526 | — | — | 1 | 8.72 |
| CHEMBL4084228 | — | — | 1 | 8.62 |
| CHEMBL4070515 | — | — | 1 | 8.57 |
| CHEMBL4061801 | — | — | 1 | 8.43 |
| CHEMBL4092338 | — | — | 1 | 8.34 |
| CHEMBL4100091 | — | — | 1 | 8.12 |
| CHEMBL4073250 | — | — | 1 | 7.62 |
| CHEMBL4076912 | — | — | 1 | 7.54 |
| CHEMBL4093989 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4066705 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4081711 | ZIMLOVISERTIB | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4093120 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4091434 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4085199 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4071526 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4084228 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4070515 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4061801 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4092338 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4100091 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4073250 | — | IC50 | = | 23.9 | nM | 7.62 |
| CHEMBL4076912 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL4093989 | — | IC50 | = | 55000.0 | nM | 4.26 |