Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5339028

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-87MG ATCC
Confidence 1 — Organism
Curated By Autocuration

Target

U-87 MG (CHEMBL614247)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and bioactivity evaluation of favorable evodiamine derivative scaffold for developing cancer therapy.
Liang Z, Wang Y, Zhang H, Deng J, Lei F, Li J, Shi T, Wang S, Li R, Wang Z.
Eur J Med Chem (2022) 239 : 114530 -114530
PubMed 35728506 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.92 5.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5079362 1 5.13
CHEMBL5085481 1 4.85
CHEMBL5401775 1 4.78
CHEMBL5073538 1 -
CHEMBL5431925 1 -
CHEMBL5396395 1 -
CHEMBL5420197 1 -
CHEMBL5082035 1 -
CHEMBL5428490 1 -
CHEMBL5072392 1 -
CHEMBL5088009 1 -
CHEMBL5089162 1 -
CHEMBL5436992 1 -
CHEMBL5069960 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5079362 IC50 = 7320.0 nM 5.13
CHEMBL5085481 IC50 = 14070.0 nM 4.85
CHEMBL5401775 IC50 = 16440.0 nM 4.78
CHEMBL5073538 IC50 > 18000.0 nM -
CHEMBL5431925 IC50 > 18000.0 nM -
CHEMBL5396395 IC50 > 18000.0 nM -
CHEMBL5420197 IC50 > 18000.0 nM -
CHEMBL5082035 IC50 > 18000.0 nM -
CHEMBL5428490 IC50 > 18000.0 nM -
CHEMBL5072392 IC50 > 18000.0 nM -
CHEMBL5088009 IC50 > 18000.0 nM -
CHEMBL5089162 IC50 > 18000.0 nM -
CHEMBL5436992 IC50 > 18000.0 nM -
CHEMBL5069960 IC50 > 18000.0 nM -