Assay Detail
Binding
CHEMBL5339113
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human Alpha-synuclein aggregation expressed in Escherichia coli incubated for 72 hrs by ThT fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bis-chalcone polyphenols with potential preventive and therapeutic effects on PD: Design, synthesis and in vitro disaggregation activity against α-synuclein oligomers and fibrils.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.99 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4075833 | — | — | 1 | 6.19 |
| CHEMBL5394205 | — | — | 1 | 6.18 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | — | 1 | 5.97 |
| CHEMBL5438558 | — | — | 1 | 5.88 |
| CHEMBL5396732 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4075833 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5394205 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL5438558 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL5396732 | — | IC50 | = | 1790.0 | nM | 5.75 |