Assay Detail
Functional
CHEMBL5339364
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Antiprolifertive activity against mouse BaF3 cells expressing TPR-MET assessed as inhibition of cell proliferation measured after 72 hrs by Cell Titer Glo assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of (S)-1-(2-(2,4-difluorophenyl)-4-oxothiazolidin-3-yl)-3-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)urea as a potential anti-colorectal cancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.73 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 7.41 |
| CHEMBL4587222 | — | — | 1 | 7.35 |
| CHEMBL5406658 | — | — | 1 | 7.28 |
| CHEMBL5436968 | — | — | 1 | 7.24 |
| CHEMBL5409449 | — | — | 1 | 7.24 |
| CHEMBL5407382 | — | — | 1 | 7.23 |
| CHEMBL4167741 | — | — | 1 | 7.18 |
| CHEMBL5411136 | — | — | 1 | 7.15 |
| CHEMBL4472209 | — | — | 1 | 7.03 |
| CHEMBL5400657 | — | — | 1 | 6.96 |
| CHEMBL5426300 | — | — | 1 | 6.85 |
| CHEMBL5393879 | — | — | 1 | 6.77 |
| CHEMBL5398121 | — | — | 1 | 6.48 |
| CHEMBL5429054 | — | — | 1 | 6.34 |
| CHEMBL5425662 | — | — | 1 | 5.89 |
| CHEMBL5395701 | — | — | 1 | 5.68 |
| CHEMBL5409164 | — | — | 1 | 5.66 |
| CHEMBL5408747 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4587222 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5406658 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5436968 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5409449 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5407382 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4167741 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5411136 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4472209 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5400657 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5426300 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5393879 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5398121 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5429054 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5425662 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5395701 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5409164 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5408747 | — | IC50 | = | 3300.0 | nM | 5.48 |