Assay Detail
Functional
CHEMBL5339373
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Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of (S)-1-(2-(2,4-difluorophenyl)-4-oxothiazolidin-3-yl)-3-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)urea as a potential anti-colorectal cancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.26 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5409449 | — | — | 1 | 7.01 |
| CHEMBL5407382 | — | — | 1 | 6.96 |
| CHEMBL5406658 | — | — | 1 | 6.85 |
| CHEMBL5436968 | — | — | 1 | 6.82 |
| CHEMBL5411136 | — | — | 1 | 6.70 |
| CHEMBL5400657 | — | — | 1 | 6.70 |
| CHEMBL5426300 | — | — | 1 | 6.68 |
| CHEMBL4472209 | — | — | 1 | 6.36 |
| CHEMBL4587222 | — | — | 1 | 6.27 |
| CHEMBL5429054 | — | — | 1 | 6.19 |
| CHEMBL4303214 | FRUQUINTINIB | 4.0 | 1 | 6.10 |
| CHEMBL4167741 | — | — | 1 | 6.09 |
| CHEMBL5398121 | — | — | 1 | 5.50 |
| CHEMBL1946170 | REGORAFENIB | 4.0 | 1 | 5.46 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 5.40 |
| CHEMBL5425662 | — | — | 1 | 5.11 |
| CHEMBL5393879 | — | — | 1 | - |
| CHEMBL5409164 | — | — | 1 | - |
| CHEMBL5395701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5409449 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5407382 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5406658 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5436968 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5411136 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5400657 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5426300 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4472209 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4587222 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5429054 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4303214 | FRUQUINTINIB | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4167741 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5398121 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1946170 | REGORAFENIB | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5425662 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5393879 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5409164 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5395701 | — | IC50 | > | 10000.0 | nM | - |