Assay Detail
Toxicity
CHEMBL5339422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HeLa S3 cells assessed as cell growth inhibition
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HeLa S3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.64 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267099 | TUBERCIDIN | — | 1 | 7.00 |
| CHEMBL5426985 | — | — | 1 | 5.31 |
| CHEMBL5415504 | — | — | 1 | 5.27 |
| CHEMBL5417816 | — | — | 1 | 4.96 |
| CHEMBL5430404 | — | — | 1 | - |
| CHEMBL5415381 | — | — | 1 | - |
| CHEMBL5396949 | — | — | 1 | - |
| CHEMBL5424607 | — | — | 1 | - |
| CHEMBL5417910 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267099 | TUBERCIDIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5426985 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5415504 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5417816 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5430404 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5415381 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5396949 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5424607 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5417910 | — | IC50 | > | 20000.0 | nM | - |