Assay Detail
Binding
CHEMBL5339525
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Inhibition of human AChE
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent advance on pleiotropic cholinesterase inhibitors bearing amyloid modulation efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.98 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5412564 | — | — | 1 | 8.10 |
| CHEMBL4856400 | — | — | 1 | 7.93 |
| CHEMBL5433139 | — | — | 1 | 7.60 |
| CHEMBL772 | RESERPINE | 4.0 | 1 | 5.77 |
| CHEMBL5412278 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5412564 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4856400 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL5433139 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL772 | RESERPINE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5412278 | — | IC50 | = | 3300.0 | nM | 5.48 |