Assay Detail
Binding
CHEMBL5339618
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain assessed as inhibition constant by competition binding assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Targeting σ<sub>2</sub>R/TMEM97 with novel aminotetralins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.64 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5400163 | — | — | 1 | 7.92 |
| CHEMBL5438672 | — | — | 1 | 7.80 |
| CHEMBL5408937 | — | — | 1 | 7.68 |
| CHEMBL5411467 | — | — | 1 | 7.48 |
| CHEMBL5406262 | — | — | 1 | 7.40 |
| CHEMBL5401174 | — | — | 1 | 7.07 |
| CHEMBL5427018 | — | — | 1 | 6.98 |
| CHEMBL5415235 | — | — | 1 | 6.85 |
| CHEMBL5419308 | — | — | 1 | 6.73 |
| CHEMBL5403404 | — | — | 1 | 6.70 |
| CHEMBL5422903 | — | — | 1 | 6.70 |
| CHEMBL5395472 | — | — | 1 | 6.65 |
| CHEMBL5401938 | — | — | 1 | 6.60 |
| CHEMBL5440859 | — | — | 1 | 6.60 |
| CHEMBL5439530 | — | — | 1 | 6.59 |
| CHEMBL5437307 | — | — | 1 | 6.58 |
| CHEMBL5393862 | — | — | 1 | 6.49 |
| CHEMBL5408800 | — | — | 1 | 6.32 |
| CHEMBL5397633 | — | — | 1 | 6.05 |
| CHEMBL5423845 | — | — | 1 | 6.01 |
| CHEMBL5402989 | — | — | 1 | 5.98 |
| CHEMBL5189158 | — | — | 1 | 5.89 |
| CHEMBL5394787 | — | — | 1 | 5.78 |
| CHEMBL5438518 | — | — | 1 | 5.68 |
| CHEMBL5419932 | — | — | 1 | 5.53 |
| CHEMBL5418564 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5400163 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL5438672 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL5408937 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL5411467 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL5406262 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL5401174 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL5427018 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL5415235 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL5419308 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL5403404 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL5422903 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL5395472 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL5401938 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL5440859 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL5439530 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL5437307 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL5393862 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL5408800 | — | Ki | = | 474.0 | nM | 6.32 |
| CHEMBL5397633 | — | Ki | = | 887.0 | nM | 6.05 |
| CHEMBL5423845 | — | Ki | = | 973.0 | nM | 6.01 |
| CHEMBL5402989 | — | Ki | = | 1054.0 | nM | 5.98 |
| CHEMBL5189158 | — | Ki | = | 1279.0 | nM | 5.89 |
| CHEMBL5394787 | — | Ki | = | 1649.0 | nM | 5.78 |
| CHEMBL5438518 | — | Ki | = | 2101.0 | nM | 5.68 |
| CHEMBL5419932 | — | Ki | = | 2944.0 | nM | 5.53 |
| CHEMBL5418564 | — | Ki | > | 10000.0 | nM | - |