Assay Detail
Binding
CHEMBL5339918
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human RIPK3 (2-328) residues expressed in baculovirus by FP assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 3 (CHEMBL1795199) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.62 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439913 | — | — | 1 | 9.05 |
| CHEMBL4779280 | — | — | 1 | 8.74 |
| CHEMBL4441118 | — | — | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439913 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4779280 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4441118 | — | IC50 | = | 8.6 | nM | 8.07 |