Assay Detail
Functional
CHEMBL5340206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human JJN-3 cells assessed as reduction in cell viability measured after 96 hrs in presence of TNF-alpha by CellTiter-Glo luminescent assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | JJN-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.64 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422160 | — | — | 1 | 5.94 |
| CHEMBL5420414 | — | — | 1 | 5.33 |
| CHEMBL4225537 | — | — | 1 | - |
| CHEMBL5436576 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422160 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5420414 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL4225537 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5436576 | — | IC50 | > | 5000.0 | nM | - |