Assay Detail
Binding
CHEMBL5340267
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Activation of PKM2 (unknown origin) incubated for 30 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Sesquiterpene Lactone Derivatives as Potent PKM2 Activators for the Treatment of Ulcerative Colitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.26 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5403098 | — | — | 1 | 6.70 |
| CHEMBL86416 | COSTUNOLIDE | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5403098 | — | EC50 | = | 202.0 | nM | 6.70 |
| CHEMBL86416 | COSTUNOLIDE | EC50 | = | 1513.0 | nM | 5.82 |