Assay Detail

CHEMBL5340592

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Binding

Inhibition of human FXIa

ChEMBL ↗

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Target

Coagulation factor XI (CHEMBL2820) ↗

Open DB target context

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Primary target Coagulation factor XI

CHEMBL2820

Anchored from Assay target.

Protein identity Coagulation factor XI

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Coagulation factor XI (CHEMBL2820) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Factor XIa Inhibitors in Anticoagulation Therapy: Recent Advances and Perspectives.

Xie Z, Meng Z, Yang X, Duan Y, Wang Q, Liao C.
J Med Chem (2023) 66 : 5332 -5363
PubMed 37037122 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.35	8.55

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL71037	—	—	1	8.55
CHEMBL5314583	FRUNEXIAN	2.0	1	8.15

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL71037	—	IC50	=	2.8	nM	8.55
CHEMBL5314583	FRUNEXIAN	IC50	=	7.1	nM	8.15