Assay Detail
Functional
CHEMBL5340647
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxant activity in New Zealand White rabbits aortic rings assessed as reduction in phenylephrine-induced contraction measured after 30 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New Generation of sGC Stimulators: Discovery of Imidazo[1,2-<i>a</i>]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.62 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5425229 | — | — | 1 | 7.57 |
| CHEMBL5415811 | — | — | 1 | 6.20 |
| CHEMBL5435708 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5425229 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5415811 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL5435708 | — | IC50 | = | 840.0 | nM | 6.08 |