Assay Detail
Binding
CHEMBL5340824
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 24 hrs by cell-based luciferase assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the First-in-Class Intestinal Restricted FXR and FABP1 Dual Modulator ZLY28 for the Treatment of Nonalcoholic Fatty Liver Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 43 | 5.91 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318457 | — | — | 1 | 6.75 |
| CHEMBL5396467 | — | — | 1 | 6.31 |
| CHEMBL5419544 | — | — | 1 | 6.24 |
| CHEMBL5437656 | — | — | 1 | 6.05 |
| CHEMBL5420532 | — | — | 1 | 6.02 |
| CHEMBL5420029 | — | — | 1 | 5.95 |
| CHEMBL5394417 | — | — | 1 | 5.87 |
| CHEMBL5437008 | — | — | 1 | 5.86 |
| CHEMBL5439401 | — | — | 1 | 5.81 |
| CHEMBL5401006 | — | — | 1 | 5.73 |
| CHEMBL5419154 | — | — | 1 | 5.73 |
| CHEMBL5436041 | — | — | 1 | 5.68 |
| CHEMBL5418217 | — | — | 1 | 5.67 |
| CHEMBL5439051 | — | — | 1 | 5.49 |
| CHEMBL5420842 | — | — | 1 | 5.46 |
| CHEMBL5409694 | — | — | 1 | - |
| CHEMBL5429880 | — | — | 1 | - |
| CHEMBL247920 | — | — | 1 | - |
| CHEMBL5412521 | — | — | 1 | - |
| CHEMBL5408182 | — | — | 1 | - |
| CHEMBL5413853 | — | — | 1 | - |
| CHEMBL5422211 | — | — | 1 | - |
| CHEMBL5406838 | — | — | 1 | - |
| CHEMBL5396259 | — | — | 1 | - |
| CHEMBL5416928 | — | — | 1 | - |
| CHEMBL5420926 | — | — | 1 | - |
| CHEMBL5425382 | — | — | 1 | - |
| CHEMBL5432375 | — | — | 1 | - |
| CHEMBL5408117 | — | — | 1 | - |
| CHEMBL5408547 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318457 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5396467 | — | EC50 | = | 491.0 | nM | 6.31 |
| CHEMBL5419544 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5437656 | — | EC50 | = | 893.0 | nM | 6.05 |
| CHEMBL5420532 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5420029 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5394417 | — | EC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL5437008 | — | EC50 | = | 1387.0 | nM | 5.86 |
| CHEMBL5439401 | — | EC50 | = | 1543.0 | nM | 5.81 |
| CHEMBL5401006 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL5419154 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL5436041 | — | EC50 | = | 2064.0 | nM | 5.68 |
| CHEMBL5418217 | — | EC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL5439051 | — | EC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL5420842 | — | EC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL5407927 | — | EC50 | - | — | - | |
| CHEMBL5393982 | — | EC50 | - | — | - | |
| CHEMBL5394780 | — | EC50 | - | — | - | |
| CHEMBL5406213 | — | EC50 | - | — | - | |
| CHEMBL5415126 | — | EC50 | - | — | - | |
| CHEMBL5440592 | — | EC50 | - | — | - | |
| CHEMBL5422288 | — | EC50 | - | — | - | |
| CHEMBL5402010 | — | EC50 | - | — | - | |
| CHEMBL5409448 | — | EC50 | - | — | - | |
| CHEMBL5417068 | — | EC50 | - | — | - | |
| CHEMBL5411250 | — | EC50 | - | — | - | |
| CHEMBL5435407 | — | EC50 | - | — | - | |
| CHEMBL5405015 | — | EC50 | - | — | - | |
| CHEMBL5409694 | — | EC50 | - | — | - | |
| CHEMBL5429880 | — | EC50 | - | — | - | |
| CHEMBL247920 | — | EC50 | > | 10.0 | nM | - |
| CHEMBL5412521 | — | EC50 | - | — | - | |
| CHEMBL5408182 | — | EC50 | - | — | - | |
| CHEMBL5413853 | — | EC50 | - | — | - | |
| CHEMBL5422211 | — | EC50 | - | — | - | |
| CHEMBL5406838 | — | EC50 | - | — | - | |
| CHEMBL5396259 | — | EC50 | - | — | - | |
| CHEMBL5416928 | — | EC50 | - | — | - | |
| CHEMBL5420926 | — | EC50 | - | — | - | |
| CHEMBL5425382 | — | EC50 | - | — | - | |
| CHEMBL5432375 | — | EC50 | - | — | - | |
| CHEMBL5408117 | — | EC50 | - | — | - | |
| CHEMBL5408547 | — | EC50 | - | — | - |